Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis. (15th January 2012)

• Record Type: Journal Article
• Authors: Machado, Marcel Cerqueira Cesar; Coelho, Ana Maria Mendonça; Carneiro D'Albuquerque, Luiz Augusto; Jancar, Sonia
• Other Names: Rakonczay Zoltan Academic Editor.
• Is Part Of: International journal of inflammation. Volume 2012(2012)
• Publication Date: 2012-01-15
• Subjects: Inflammation -- Periodicals; Inflammation; Inflammation; Periodicals; 617.22
• DOI: 10.1155/2012/270319
• Languages: English
• ISSNs: 2090-8040

Abstract

Abstract : Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status called inflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation.