Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media. Issue 23 (30th April 2019)

• Record Type: Journal Article
• Authors: Nie, Hui-Jun; Guo, An-Di; Lin, Hai-Xia; Chen, Xiao-Hua
• Is Part Of: RSC advances. Volume 9:Issue 23(2019)
• Page Start: 13249
• Page End: 13253
• Publication Date: 2019-04-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra02466b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A straightforward protocol for the rapid construction of privileged indazolone architectures suggests a new avenue of great importance to medicinal chemistry. Abstract : Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2- N -substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggests a new avenue of great importance to medicinal chemistry.