Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?. (18th February 2014)

• Record Type: Journal Article
• Authors: Hue, Susan Swee-Shan; Suhail, Sufi Muhammad; Choo, Jason Chon Jun; Yusof, Nurhashikin; Loh, Alwin Hwai-Liang; Salcido-Ochoa, Francisco
• Other Names: Honda K. Academic Editor.; Satoskar A. Academic Editor.; Schaller M. Academic Editor.; Urushihara M. Academic Editor.
• Is Part Of: ISRN pathology. Volume 2014(2014)
• Publication Date: 2014-02-18
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.07
• DOI: 10.1155/2014/640829
• Languages: English
• ISSNs: 2090-570X

Abstract

Abstract : Minimal change disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of minimal change disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary minimal change disease is still largely unclear. We here propose a theoretical model based on the available evidence.