Asymmetric Core–Shell Gold Nanoparticles and Controllable Assemblies for SERS Ratiometric Detection of MicroRNA. Issue 22 (28th April 2021)

• Record Type: Journal Article
• Authors: Zhu, Rong; Feng, Hongjuan; Li, Qingqing; Su, Lichao; Fu, Qinrui; Li, Juan; Song, Jibin; Yang, Huanghao
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 22(2021)
• Page Start: 12560
• Page End: 12568
• Publication Date: 2021-04-28
• Subjects: asymmetric optical properties -- controllable assembly -- microRNA-21 -- SERS-based ratiometric detection -- symmetry-breaking nanomaterials; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202102893
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage of (ca. 100/75/50/25 %) are presented. The internal nanogap between the partial Au shell and core caused asymmetric optical behavior; tunability depends on the degree of Au shell coverage and structural asymmetry. The shell‐to‐shell or core‐to‐core JAuNNDs(50 %) were self‐assembled from amphiphilic JAuNNPs(50 %) by tuning the hydrophilic and hydrophobic polymer brushes on the Au core or shell. The positions of electromagnetic field enhancement of JAuNNDs varied with geometrical configurations because of hybridized plasmonic coupling effects. Furthermore, DNA linkers were utilized to form JAuNND12 (50 %). By combining with Raman molecules, ratiometric SERS signals could be generated, enabling JAuNND12 (50 %) to image the distribution of miR‐21 in living cells and tumors. Asymmetric JAuNNPs allowed facile conjugation of various linkage molecules to fabricate dimeric nanostructures. Abstract : A series of asymmetrical plasmonic core–shell nanoparticles (JAuNNPs) are created, displaying tailorable optical properties. Using amphiphilic polymer brushes, core‐to‐core or shell‐to‐shell dimers with controllable spatial precision and position of EM field enhancement are fabricated. DNA linkers are utilized to form JAuNND12 (50 %), enabling them to image the distribution of miR‐21 in living cells and tumors.