Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021). (19th May 2021)

• Record Type: Journal Article
• Authors: de Araujo, Aline D.; Nguyen, Huy T.; Fairlie, David P.
• Is Part Of: Chembiochem. Volume 22:Number 10(2021)
• Page Start: 1686
• Page End: 1686
• Publication Date: 2021-05-19
• Subjects: conjugation -- cysteine lipidation -- peptides -- stapling; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202100189
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : Linear and branched hydrocarbon chains may be appended or crosslinked at selected cysteine positions in unprotected peptides and proteins. The method involves nucleophilic substitution assisted by a simple zinc salt under mild conditions and can be applied at late stages of synthesis. More information can be found in the Full Paper by A. D. de Araujo, H. T. Nguyen, D. P. Fairlie .