Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus. (26th March 2014)

• Record Type: Journal Article
• Authors: Meguro, Shu; Tomita, Masuomi; Katsuki, Takeshi; Kato, Kiyoe; Oh, Henpiru; Ainai, Akira; Ito, Ryo; Kawai, Toshihide; Itoh, Hiroshi; Hasegawa, Hideki
• Other Names: Pérez-López Faustino R. Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2014(2014)
• Publication Date: 2014-03-26
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2014/703696
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Introduction . Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods . We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n = 133, 115 men and 18 women; age 64.7 ± 11.5 years; HbA1c 8.1 ± 1.6 %). Plasma level of LL-37 was measured by ELISA. Results . Mean plasma LL-37 level was 71.2 ± 22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r = − 0.450, P < 0.01 ), triglyceride (r = 0.445, P < 0.01 ), and high sensitive C-reactive protein (r = 0.316, P < 0.01 ) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β = − 0.411, P < 0.01 ) and high sensitive C-reactive protein (β = 0.193, P < 0.05 ). Conclusion . Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.