An idea to explore: Visualization of ionization of amino acids using Mathematica. Issue 3 (23rd October 2020)

• Record Type: Journal Article
• Authors: Novak, Igor
• Is Part Of: Biochemistry and molecular biology education. Volume 49:Issue 3(2021)
• Page Start: 333
• Page End: 345
• Publication Date: 2020-10-23
• Subjects: positive and negative cooperativity -- teaching of ionization of amino acids -- variation of amino acid charge with pH -- visualization of intramolecular interactions pertaining to amino acid ionization; Biochemistry -- Study and teaching -- Periodicals; Molecular biology -- Study and teaching -- Periodicals; 572.071
• DOI: 10.1002/bmb.21470
• Languages: English
• ISSNs: 1470-8175

Abstract

Abstract: Ionization of amino acids (AA) is very important concept in biochemistry. We integrate the mathematical concept of probability with biochemically relevant process of AA ionization. We visualize the ionization process with Mathematica software discussing intramolecular interactions between weakly acidic/basic functional groups and charge–pH variation of amino acids in water solution. The visualizations rely on the notion of probability of ionization of functional groups and demonstrate how the extent of ionization and charge varies with pH of the solution. The examples described include amino acids and weak diprotic acids and bases. The aim is to help students better appreciate the importance and consequences of AA ionization and correct some misconceptions.