Bi(OTf)3‐Mediated (4+1) Annulation of α‐Sulfonyl o‐Hydroxyacetophenones with α‐Hydroxy Arylketones to Access Sulfonyl 2‐Aroylbenzofurans. Issue 10 (19th March 2021)

• Record Type: Journal Article
• Authors: Chang, Meng‐Yang; Chen, Kuan‐Ting
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 10(2021)
• Page Start: 2594
• Page End: 2609
• Publication Date: 2021-03-19
• Subjects: 2-Aroylbenzofurans -- Double Cyclocondensation -- o-Hydroxyacetophenones -- α-Hydroxy Arylketones -- (4+1) Annulation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100143
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: In this paper, a high‐yield, facile route for the scalable synthesis of sulfonyl 2‐aroylbenzofurans via a Bi(OTf)3 ‐mediated intermolecular double cyclocondensation of α‐sulfonyl o ‐hydroxyacetophenones with substituted α‐hydroxy arylketones under mild open‐vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate‐promoted reactions and conditions are investigated for the efficient one‐pot (4+1) annulation reaction. Abstract :