Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis. (12th June 2012)

• Record Type: Journal Article
• Authors: Makiishi, Tetsuya; Nishimura, Naomasa; Yoshioka, Keiko; Yamamoto, Shinya; Mitsuhashi, Ryuichi; Maeda, Sayako; Konishi, Takashi; Hirose, Kunihiko
• Other Names: Springate James E. Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2012(2012)
• Publication Date: 2012-06-12
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2012/768316
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Background . To address the cause(s) of the significant differences in chloride (Cl - ) concentrations between point-of-care blood gas analyzers and central laboratory analyzers. Methods . Cl - concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer (Hitachi7600) were collected in patients with severe acidemia (pH < 7.20 ) (n = 32 ) and were examined for correlations between differences in Cl - and factors associated with the acid-base status. Cl - concentrations were measured with both analyzers for samples with different concentrations of lactate, inorganic phosphate, or bicarbonate (HCO 3 − ). Results . The differences in Cl - concentrations were correlated with HCO 3 − concentrations (r = 0.72, P < 0.0001 ) and anion gap (r = 0.69, P < 0.0001 ). Only the addition of HCO 3 − proportionately increased Cl - levels measured by a Hitachi7600, but it did not affect those measured by an ABL800FLEX. Conclusion . Cl - measurements with some analyzers may be influenced by HCO 3 − concentrations, which could result in the observed discrepancies.