Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus. (18th December 2012)

• Record Type: Journal Article
• Authors: Meguro, Shu; Tomita, Masuomi; Kabeya, Yusuke; Katsuki, Takeshi; Oikawa, Yoichi; Shimada, Akira; Kawai, Toshihide; Itoh, Hiroshi; Atsumi, Yoshihito
• Other Names: Rossing Peter Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2012(2012)
• Publication Date: 2012-12-18
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2012/687867
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Introduction . There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods . We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m 2 . eGFR strata were defined by baseline eGFR value as follows: stratum 1: ≥90, stratum 2: ≥60, <90, and stratum 3: ≥30, <60. Results . The annual eGFR decline was 2.3 ± 5.4 mL/min/1.73 m 2 in overall subjects. Multiple linear regression analysis demonstrated that age, male sex, systolic blood pressure, logarithmically transformed albumin excretion rate (AER), eGFR strata, and hemoglobin concentration were significantly correlated with the annual eGFR decline. When stratified by eGFR, the factors that showed a significant correlation were different among eGFR strata. AER was significantly correlated with annual eGFR decline in all eGFR strata. Hemoglobin concentration showed a significant correlation only in the advanced eGFR stratum. Conclusion . The factors correlated with the annual eGFR decline were different among eGFR strata in type 2 diabetes mellitus, and hemoglobin concentration and AER were important factors for renal deterioration, especially in the advanced eGFR stratum.