Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease. (16th March 2013)

• Record Type: Journal Article
• Authors: Strandhave, Charlotte; Svensson, My; Krarup, Henrik; Christensen, Jeppe Hagstrup
• Other Names: Martín-Malo Alejandro Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2013(2013)
• Publication Date: 2013-03-16
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2013/650847
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Sudden cardiac death and atherosclerosis have a major impact on cardiovascular mortality in chronic kidney disease (CKD). Inflammation with elevated high-sensitive C-reactive protein (hs-CRP) is involved in both sudden cardiac death and atherosclerosis, and decreased heart rate variability (HRV) is a predictor of both sudden cardiac death and atherosclerosis. Haptoglobin (Hp) is characterised by three genotypes (1-1, 2-1, and 2-2) with different antioxidant abilities. The aim was to examine whether HRV and hs-CRP were associated with Hp genotype in CKD patients. Fifty-six patients with CKD stage 2–5 were included. Hp genotype was determined by high-performance liquid chromatography. HRV was analysed from the 24 h Holter recordings. Hs-CRP was measured using an immunoturbidimetric assay. The results show that the HRV indices SDNN and SDANN were significantly lower in the Hp 2-2 patients (P = 0.02 and 0.04, resp.). In an adjusted linear regression model, Hp 2-2 was associated with both SDNN (P = 0.005 ) and SDANN (P = 0.01 ). Hs-CRP was higher in the Hp 2-2 patients (P = 0.002 ). In an adjusted linear regression model, the association between Hp 2-2 and hs-CRP remained significant (P = 0.003 ). In conclusion, a negative association was observed between Hp 2-2 and HRV, and Hp 2-2 was positively associated with hs-CRP in CKD patients.