Bounded input impulsive control for scheduling therapies. (June 2021)

• Record Type: Journal Article
• Authors: Hernandez-Mejia, Gustavo; Du, Xin; Alanis, Alma Y.; Hernandez-Vargas, Esteban A.
• Is Part Of: Journal of process control. Volume 102(2021)
• Page Start: 34
• Page End: 43
• Publication Date: 2021-06
• Subjects: Impulsive control -- Inverse optimal control -- PK/PD dynamics -- Personalized medicine; Process control -- Periodicals; Fabrication -- Contrôle -- Périodiques; Process control; Periodicals; Electronic journals; 660.281
• DOI: 10.1016/j.jprocont.2021.03.003
• Languages: English
• ISSNs: 0959-1524

Abstract

Abstract: Scheduling therapies is a central paradigm in personalized medicine. Modeling and control theoretical approaches are opening an avenue for linking interactions between drugs and diseases in the host. In this paper, considering an inverse optimal approach, we formulate a framework based on a bounded input impulsive control to schedule therapies. Results for stability with a bounded input are introduced. We show the application of the algorithms with illustrative examples as well as the biomedical application of the long-term impact of therapies for a functional HIV cure. Results highlight that the proposed framework has the potential for tailoring therapies in different diseases such as diabetes, cancer, and infectious diseases. Highlights: Impulsive control law using an inverse optimal approach. Scheduling Therapies in Infectious Diseases. Bounded Input Impulsive Control.