The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study. Issue 3 (9th April 2021)

• Record Type: Journal Article
• Authors: Bingoel, Alperen S.; Krezdorn, Nicco; Kaltenborn, Alexander; Dastagir, Khaled; Jokuszies, Andreas; Mett, Tobias R.; Vogt, Peter M.
• Is Part Of: Wound repair and regeneration. Volume 29:Issue 3(2021)
• Page Start: 478
• Page End: 485
• Publication Date: 2021-04-09
• Subjects: chronic wounds -- negative pressure wound therapy -- Pyoderma gangrenosum -- skin grafting -- wound healing; Wound healing -- Periodicals; Regeneration (Biology) -- Periodicals; 617.14
• DOI: 10.1111/wrr.12918
• Languages: English
• ISSNs: 1067-1927

Abstract

Abstract: Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Nevertheless, surgical treatment might be necessary for reconstruction, once the progression of these wounds is controlled. We aimed to characterize medical findings in Pyoderma patients with extensive defects to assess the surgical procedures and their outcome. A retrospective study was conducted at our centre over an 18‐year period. Inclusion criteria were the diagnosis of Pyoderma gangrenosum and at least one surgical intervention. Descriptive statistics were used to analyse the data. Sixteen patients were included. The mean size of the lesions was noted with 12 × 8 cm. Surgical procedures comprised debridements/necrectomies, allograft conditioning, negative pressure wound therapy, skin grafts, and microvascular free flaps. Seven patients were discharged with healed wounds, six with minor wound healing disturbances. Three patients succumbed to their underlying diseases. Drug‐based therapy can stop the progress of Pyoderma, but severe tissue loss can be a persistent problem. According to our data, reconstructive‐surgical treatments (debridement, autologous and allogenous skin transplantation and microvascular free flaps) act as an integral component of the therapy and can be safe options for selected patients. Furthermore, we provide an algorithm that we follow at our department in severe cases.