Fast, regional three‐dimensional hybrid (1D‐Hadamard 2D‐rosette) proton MR spectroscopic imaging in the human temporal lobes. (23rd March 2021)

• Record Type: Journal Article
• Authors: Tal, Assaf; Zhao, Tiejun; Schirda, Claudiu; Hetherington, Hoby P.; Pan, Jullie W.; Gonen, Oded
• Is Part Of: NMR in biomedicine. Volume 34:Number 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-23
• Subjects: brain -- Hadamard spectroscopic imaging -- hippocampus -- magnetic resonance spectroscopic imaging -- rosette spectroscopic imaging; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4507
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : 1 H‐MRSI is commonly performed with gradient phase encoding, due to its simplicity and minimal radio frequency (RF) heating (specific absorption rate). Its two well‐known main problems—(i) "voxel bleed" due to the intrinsic point‐spread function, and (ii) chemical shift displacement error (CSDE) when slice‐selective RF pulses are used, which worsens with increasing volume of interest (VOI) size—have long become accepted as unavoidable. Both problems can be mitigated with Hadamard multislice RF encoding. This is demonstrated and quantified with numerical simulations, in a multislice phantom and in five healthy young adult volunteers at 3 T, targeting a 2‐cm thick temporal lobe VOI through the bilateral hippocampus. This frequently targeted region (e.g. in epilepsy and Alzheimer's disease) is subject to strong, 1‐2 ppm.cm ‐1 regional B0, susceptibility gradients that can dramatically reduce the signal‐to‐noise ratio (SNR) and water suppression effectiveness. The chemical shift imaging (CSI) sequence used a 3‐ms Shinnar–Le Roux (SLR) 90° RF pulse, acquiring eight steps in the slice direction. The Hadamard sequence acquired two overlapping slices using the same SLR 90° pulses, under twofold stronger gradients that proportionally halved the CSDE. Both sequences used 2D 20 × 20 rosette spectroscopic imaging (RSI) for in‐plane spatial localization and both used RF and gradient performance characteristics that are easily met by all modern MRI instruments. The results show that Hadamard spectroscopic imaging (HSI) suffered dramatically less signal bleed within the VOI compared with CSI (<1% vs. approximately 26% in simulations; and 5%–8% vs. >50%) in a phantom specifically designed to test these effects. The voxels' SNR per unit volume per unit time was also 40% higher for HSI. In a group of five healthy volunteers, we show that HSI with in‐plane 2D‐RSI facilitates fast, 3D multivoxel encoding at submilliliter spatial resolution, over the bilateral human hippocampus, in under 10 min, with negligible CSDE, spectral and spatial contamination and more than 6% improved SNR per unit time per unit volume. Abstract : We present a novel 3D 1 H‐MRSI sequence comprising a 1D Hadamard RF‐encoding hybrid with 2D‐RSI that is: (a) tailored to thin slab VOIs; (b) minimizes both the extraneous and interslice signal bleeds that are characteristic of CSI; and (c) fast enough (<10 min) to fit into clinical protocols. The results show a dramatic 25% to 1% reduction in interslice signal bleed and a 40% improvement in SNR (due to better slice profiles and reduced bleeds) in phantoms and simulations and 6% in the human brain.