Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach. (11th February 2014)

• Record Type: Journal Article
• Authors: Yang, Jinlin; Wang, Rui; Zhang, Wenyan; Zhuang, Wen; Wang, Mojin; Tang, Chengwei
• Other Names: Fan D. Academic Editor.
• Is Part Of: Gastroenterology research and practice. Volume 2014(2014)
• Publication Date: 2014-02-11
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33005
• DOI: 10.1155/2014/140587
• Languages: English
• ISSNs: 1687-6121

Abstract

Abstract : The present study was undertaken to clarify the association of the clinicopathological features of hepatoid adenocarcinoma (HAC) in the stomach, a special kind of carcinoma that histologically resembled hepatocellular carcinoma (HCC) and is characterized by large amounts of α -fetoprotein (AFP) in serum, with the clinical prognosis. We collected the data of the clinicopathological features and the follow-up information from a total of 31 HACs from January 2005 to December 2012 in our hospital. High lymphatic (54.8%) and distant (25.8%) metastasis rates before surgery, large proportion of advanced HACs (71.0%) at admission, short median overall survival time (6 months), and low three-year survival rate (22.6%) suggested that HAC in the stomach was an aggressive disease, resulting in a poor prognosis. And pTNM stages, immunohistochemical staining of AFP, CEA, CK7, and CK20 had statistically relation with the survival as the independent risk factors, P < 0.05 . Therefore, early and clear differentiation of HAC from cancerous or noncancerous conditions with AFP elevation and assessment of high risk patients by histopathology may improve the clinical prognosis.