Laryngeal Synovial Sarcoma: A Rare Clinical Entity. (8th July 2013)

• Record Type: Journal Article
• Authors: Saxby, Clair; Bova, Ron; Edwards, Melanie
• Other Names: Mevio E. Academic Editor.; Morshed K. Academic Editor.; Orita Y. Academic Editor.; Timms M. S. Academic Editor.
• Is Part Of: Case reports in otolaryngology. Volume 2013(2013)
• Publication Date: 2013-07-08
• Subjects: Otolaryngology -- Periodicals; Otolaryngology -- Case studies -- Periodicals; Otolaryngology; Otorhinolaryngologic Diseases; Otolaryngology; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.51
• DOI: 10.1155/2013/578606
• Languages: English
• ISSNs: 2090-6765

Abstract

Abstract : Introduction . Synovial sarcomas (SS) are aggressive malignant soft tissue tumours that are thought to arise from pluripotent mesenchymal cells. Clinical Report . A 20-year-old male presented with an acute onset of respiratory stridor. Computer tomography scanning confirmed a mass arising from the left supraglottic larynx and an emergency tracheostomy was performed. A diagnosis of biphasic synovial sarcoma was formed. A total laryngectomy and left hemithyroidectomy was performed in conjunction with a left modified radical neck dissection. The patient received adjuvant chemotherapy followed by a course of radiotherapy and remains alive and disease free at 18 months after treatment. Discussion . Prognosis for patients with SS is related to primary tumour extent, grade, and size. The presence of the diagnostic translocation, t(X;18), is being targeted and hopefully will lead to the development of new therapeutics (Guadagnolo et al., 2007). Conclusion . Laryngeal SS remains a rare and poorly understood entity. A multidisciplinary approach to treatment is essential and long-term followup is imperative.