A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis. (15th April 2014)

• Record Type: Journal Article
• Authors: Saito, Eiko; Sato, Shinji; Nogi, Shinichi; Sasaki, Noriko; Chinen, Naofumi; Honda, Kiri; Wakabayashi, Takayuki; Yamada, Chiho; Nakamura, Naoya; Suzuki, Yasuo
• Other Names: Kuwana Masataka Academic Editor.
• Is Part Of: Case reports in rheumatology. Volume 2014(2014)
• Publication Date: 2014-04-15
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Case studies -- Periodicals; Rheumatic Diseases; Connective Tissue Diseases; Rheumatology; Periodicals; Electronic journals; Case studies; Periodicals; 616.723
• DOI: 10.1155/2014/386328
• Languages: English
• ISSNs: 2090-6889

Abstract

Abstract : A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. Because of gradually worsening arthritis, tocilizumab was administered and arthritis improved markedly. Interestingly, lymphadenopathy and PBC improved simultaneously. This suggested that interleukin-6 might play an important role in reactive lymphadenopathy and PBC associated with RA/lSSc.