Lung Cancer Associated with Neurofibromatosis Type I. (28th February 2013)

• Record Type: Journal Article
• Authors: Oikonomou, Anastasia; Mikroulis, Dimitrios; Mintzopoulou, Paraskevi; Lukman, Lawal; Prassopoulos, Panos
• Other Names: Bölke E. Academic Editor.; Byrd R. P. Academic Editor.; Kocakoc E. Academic Editor.; Lampmann L. Academic Editor.
• Is Part Of: Case reports in radiology. Volume 2013(2013)
• Publication Date: 2013-02-28
• Subjects: Radiology -- Periodicals; Radiology -- Case studies -- Periodicals; Medical radiology -- Periodicals; Radiology; Radiology; Medical radiology; Periodicals; Electronic journals; Case studies; Periodicals; 616.0757
• DOI: 10.1155/2013/869793
• Languages: English
• ISSNs: 2090-6862

Abstract

Abstract : Lung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. A solitary ill-defined nodule of a ground-glass opacity was detected incidentally in the middle lobe with no associated lymphadenopathy or metastatic disease. Several thin-walled lung cysts were also seen in the lower lobes. Histological analysis of the nodule after middle lobectomy revealed well-differentiated adenocarcinoma. The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup.