Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde. (21st May 2014)

• Record Type: Journal Article
• Authors: Sun, Ruiqi; Jiang, Haiyan; Zhang, Wenjuan; Yang, Kai; Wang, Chengfang; Fan, Li; He, Qing; Feng, Jiangbin; Du, Shushan; Deng, Zhiwei; Geng, Zhufeng
• Other Names: Wu Shi-Biao Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-05-21
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/580483
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10- O -methylhernovine (1 ), nantenine (2 ), corytuberine (3 ), lagesianine A (4 ), and dihydrocryptopine (9 ) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC50 values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μ M, respectively.