Assessment of TREM2 rs75932628 variant's association with Parkinson's disease in a Greek population and Meta-analysis of current data. (3rd June 2021)

• Record Type: Journal Article
• Authors: Dardiotis, Efthimios; Rikos, Dimitrios; Siokas, Vasileios; Aloizou, Athina-Maria; Tsouris, Zisis; Sakalakis, Evagelos; Brotis, Alexandros G.; Bogdanos, Dimitrios P.; Hadjigeorgiou, Georgios M.
• Is Part Of: International journal of neuroscience. Volume 131:Number 6(2021)
• Page Start: 544
• Page End: 548
• Publication Date: 2021-06-03
• Subjects: PD -- TREM2 -- rs75392628 -- R47H -- genetic variant -- neurodegeneration -- meta-analysis; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2020.1750388
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract: Background: Α number of genetic variants are considered to confer susceptibility to Parkinson's disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting. Objective: Detection of a possible contribution of rs75392628 variant of TREM2 gene to PD risk. Methods: A total of 358 PD patients and 358 healthy controls genotyped for rs75392628. In addition, a meta-analysis was performed by merging our results with those from previous studies. Results: The rare variant of rs75932628 (47H) of TREM2 gene was not detected on cohort. Meta-analysis of a total of 9271 PD cases and 9777 controls across 14 independent PD data sets from 9 studies, including the present study, did not show any statistically significant effect of rs75392628 on PD risk (ORFE :1.54 95% CI:0.87-2.73. ORRE : 1.54, 95%CI: 0.71-3.32). Conclusions: Rs75392628 TREM2 variant is rather unlikely to be a major genetic risk contributor of PD.