A facile way to synthesize a photocrosslinkable methacrylated chitosan hydrogel for biomedical applications. Issue 10 (3rd July 2021)

• Record Type: Journal Article
• Authors: Samani, Saeed; Bonakdar, Shahin; Farzin, Ali; Hadjati, Jamshid; Azami, Mahmoud
• Is Part Of: International journal of polymeric materials. Volume 70:Issue 10(2021)
• Page Start: 730
• Page End: 741
• Publication Date: 2021-07-03
• Subjects: Chitosan -- hydrogel -- methacrylation -- polysaccharide -- tissue engineering; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2020.1760274
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: In this study, we introduced a novel and modified method to synthesize photocrosslinkable chitosan hydrogel. Three methacrylated samples under two concentrations of methacrylic anhydride and using EDC/NHS as a crosslinker were prepared. Methacrylated chitosan obtained under controlled conditions and using EDC/NHS had significant coupling efficiency and capacity of gel formation compared to other samples. Diluted culture media provided a favorable solubility condition for methacrylated chitosan and could be tolerated by cells during gelation time. The hydrogels included interconnected pores ranging 100–300 µm and swelling ratios of 40–400%. The results opened the new aspects for developing novel biomaterials in cell-based therapies. Graphical Abstract: