2-Thiobarbituric acid addition improves structural integrity and controlled drug delivery of biocompatible pectin hydrogels. Issue 10 (3rd July 2021)

• Record Type: Journal Article
• Authors: Güner, O. Z.; Kocaaga, B.; Batirel, S.; Kurkcuoglu, O.; Güner, F. S.
• Is Part Of: International journal of polymeric materials. Volume 70:Issue 10(2021)
• Page Start: 703
• Page End: 711
• Publication Date: 2021-07-03
• Subjects: Biopolymers -- drug delivery systems -- hydrogels -- molecular dynamics -- simulations; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2020.1760272
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Thiolated polymers are commonly preferred for biomedical applications with their good permeation properties providing them higher bioavailability. However, the thiolation process is mostly time-consuming series of chemical reactions. This study describes a simple irreversible thiol group integration to the pectin hydrogels by noncovalent bonding. We used 2-thiobarbituric acid (TBA) for thiolation. We proved with full-atom molecular dynamics simulations and experimental methods that TBA desertion is negligible. Pectin hydrogels become more flexible and their disintegration is delayed from 4 h up to four days with TBA addition. Also, hydrogels can successfully deliver the model drug, theophylline, showing a controlled release profile. Graphical Abstract: