The effect of endometrial thickness and pattern on the success of frozen embryo transfer cycles and gestational age accuracy. (4th May 2021)

• Record Type: Journal Article
• Authors: Shalom-Paz, Einat; Atia, Nitzan; Atzmon, Yuval; Hallak, Mordechai; Shrim, Alon
• Is Part Of: Gynecological endocrinology. Volume 37:Number 5(2021)
• Page Start: 428
• Page End: 432
• Publication Date: 2021-05-04
• Subjects: Endometrial thickness -- crown-rump length -- frozen embryo transfer -- pregnancy rate -- endometrial pattern; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2020.1821359
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Objective: To evaluate the relationship between endometrial thickness measured before embryo transfer, and pregnancy outcomes in frozen-thawed embryo transfer (FET). Methods: We retrospectively analyzed outcomes of all consecutive FET cycles, from January 2012 to August 2018. Based on ROC analysis for endometrial thickness, we found 8 mm was a reliable cutoff point to predict pregnancy prior to embryo transfer. Accordingly, the cycles were divided into Group A: cycles with endometrial thickness ≤ 8 mm and Group B: > 8 mm. Results: Group A included 485 FET cycles and group B included 626 cycles. Compared with group A, Group B had significantly higher chemical and clinical pregnancy rates (30.3 vs. 24.6%; p = .046, and 24.0 vs. 18.6%; p = .036), respectively. In multivariate analysis, endometrial thickness and the protocols used were the only parameters influencing the chance to achieve pregnancy, with odds ratio 1.54 (95%CI 1.07–2.22, p = .019) for the endometrium and odds ratio 1.95 (95%CI 1.31–2.9; p = .001) to the protocol used. Endometrial thickness might predict crown-rump length (CRL) discordancy with odds ratio 4.61 ( p = .001; 95% CI 1.42–14.92). Compared with group B, Group A had more cases of overt discordancy (13.3 vs. 4%; p = .016). Conclusions: For patients undergoing FET cycles, endometrial thickness and treatment protocol may predict the chemical and clinical pregnancy rates, as well as CRL discordancy. Summary: Endometrial thickness and preparation improved pregnancy rate in FET cycles and significantly greater crown-rump length discordancy was observed with thinner endometria.