The mystery of monozygotic twinning I: What can Amyoplasia tell us about monozygotic twinning and the possible role of twin–twin transfusion?. Issue 6 (24th March 2021)

• Record Type: Journal Article
• Authors: Hall, Judith G.
• Is Part Of: American journal of medical genetics. Volume 185:Issue 6(2021)
• Page Start: 1816
• Page End: 1821
• Publication Date: 2021-03-24
• Subjects: Amyoplasia -- anterior horn cell -- deformation -- monozygotic twinning -- twin–twin transfusion -- vascular accident; Medical genetics -- Periodicals; 616.14205
• DOI: 10.1002/ajmg.a.62172
• Languages: English
• ISSNs: 1552-4825

Abstract

Abstract: Amyoplasia is a very specific, nongenetic clinically recognizable form of arthrogryposis, representing about one‐third of individuals with arthrogryposis surviving the newborn period. There is a markedly increased number of individuals with Amyoplasia who are one of monozygotic (MZ) twins, with the other twin being normal. Thus, it would appear that Amyoplasia is definitely associated with and may be caused by an MZ twinning event. The twin–twin transfusion seen in MZ twins could play an etiologic role in producing Amyoplasia. In this article, Amyoplasia twinning is compared to twinning in other forms of arthrogryposis. The accompanying paper examines various types of MZ twinning (Hall, 2021). Amyoplasia is primarily associated with spontaneous MZ twinning.