In vivo oral insulin delivery via covalent organic frameworks. Issue 17 (6th April 2021)

• Record Type: Journal Article
• Authors: Benyettou, Farah; Kaddour, Nawel; Prakasam, Thirumurugan; Das, Gobinda; Sharma, Sudhir Kumar; Thomas, Sneha Ann; Bekhti-Sari, Fadia; Whelan, Jamie; Alkhalifah, Mohammed A.; Khair, Mostafa; Traboulsi, Hassan; Pasricha, Renu; Jagannathan, Ramesh; Mokhtari-Soulimane, Nassima; Gándara, Felipe; Trabolsi, Ali
• Is Part Of: Chemical science. Volume 12:Issue 17(2021)
• Page Start: 6037
• Page End: 6047
• Publication Date: 2021-04-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc05328g
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin. Abstract : With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.