Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids. Issue 17 (13th April 2021)

• Record Type: Journal Article
• Authors: Herschede, Sarah R.; Gneid, Hassan; Dent, Taylor; Jaeger, Ellen B.; Lawson, Louise B.; Busschaert, Nathalie
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 17(2021)
• Page Start: 3838
• Page End: 3843
• Publication Date: 2021-04-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00263e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : In this manuscript we report a small molecule that can selectively bind to the bacterial lipid phosphatidylethanolamine and consequently functions as an antibacterial agent against certain Gram-positive bacteria. Abstract : An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.