An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization. Issue 18 (28th April 2021)

• Record Type: Journal Article
• Authors: Štarha, Pavel; Drahoš, Bohuslav; Herchel, Radovan
• Is Part Of: Dalton transactions. Volume 50:Issue 18(2021)
• Page Start: 6071
• Page End: 6075
• Publication Date: 2021-04-28
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt00740h
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Complex cis -[PtI2 (NH3 )(pic)] (pic = 2-methylpyridine), an iodido analogue of picoplatin, released the N-donor pic ligand in solution and isomerized, which complicates its subsequent testing for cytotoxicity. Abstract : Complex cis -[PtI2 (NH3 )(pic)] (1 ; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2 ), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1 .