A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf. Issue 10 (19th May 2021)

• Record Type: Journal Article
• Authors: Foudjo Melacheu Laura, Gertrude; Mfotie Njoya, Emmanuel; Jouda, Jean-Bosco; Wakeu Kweka, Brussine Nadege; Djama Mbazoa, Céline; Wang, Fei; Seguin, Elisabeth; Wandji, Jean
• Is Part Of: Natural product research. Volume 35:Issue 10(2021)
• Page Start: 1590
• Page End: 1595
• Publication Date: 2021-05-19
• Subjects: Tabernaemontana inconspicua -- indole alkaloids -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1628749
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new indole alkaloid derivative, 5, 6-dioxo-11-hydroxy voacangine (1 ) together with four known compounds (2 -5 ), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 µM and 2.19 µM after 24 and 48 hours, respectively. GRAPHICAL ABSTRACT: