Cytotoxic p-terphenyls from the deep-sea-derived Aspergillus candidus. Issue 10 (19th May 2021)

• Record Type: Journal Article
• Authors: Lin, Yu-Kun; Xie, Chun-Lan; Xing, Cui-Ping; Wang, Bao-Qu; Tian, Xiao-Xue; Xia, Jin-Mei; Jia, Ling-Yun; Pan, Ying-Ni; Yang, Xian-Wen
• Is Part Of: Natural product research. Volume 35:Issue 10(2021)
• Page Start: 1627
• Page End: 1631
• Publication Date: 2021-05-19
• Subjects: Fungus -- the Atlantic Ocean -- in vitro -- antitumor -- anti-allergy; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1633651
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: From the deep-sea-derived fungus Aspergillus candidus, one novel (1 ) and three known (2 –4 ) p -terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor bioactivities. Compounds 3 and 4 showed potent antiproliferative effect against four cancer cells of Hela, Eca-109, Bel-7402, and PANC-1 with IC50 values ranging from 5.5 μ M to 9.4 μ M. GRAPHICAL ABSTRACT: