Comparisons of different vitamin D supplementation for prevention of osteoporotic fractures: a Bayesian network meta-analysis and meta-regression of randomised controlled trials. (19th May 2021)

• Record Type: Journal Article
• Authors: Li, Shuo; Xi, Chunyang; Li, Liangliang; Long, Zhiping; Zhang, Nannan; Yin, Huihui; Xie, Kun; Wu, Zhen; Tian, Jingshen; Wang, Fan; Wang, Maoqing
• Is Part Of: International journal of food sciences and nutrition. Volume 72:Number 4(2021)
• Page Start: 518
• Page End: 528
• Publication Date: 2021-05-19
• Subjects: Bayesian network meta-analysis -- meta-regression -- vitamin D supplementation -- osteoporosis -- fractures; Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.1080/09637486.2020.1830264
• Languages: English
• ISSNs: 0963-7486

Abstract

Abstract: Previous randomised controlled trials have shown the controversial effectiveness of oral vitamin D supplementation in preventing osteoporotic fractures. PubMed, EMBASE and Cochrane Library electronic databases were searched. Pairwise meta-analysis, Bayesian network meta-analysis and meta-regression were applied. A total of 33 studies containing 83, 083 participants were included. Oral vitamin D supplementation showed no statistically significant on reducing the risk of total fractures (RR = 0.96, 95%CI = 0.87–1.05 p = 0.389). Vitamin D3 (700–800IU/d) plus calcium showed statistical significance in reducing the incidence of total, hip and non-vertebral fractures in the pairwise meta-analysis. Significant reductions were specifically identified in female in total and hip fractures. However, we did not observe any above significant results using Bayesian network meta-analyses. Strikingly, a meta-regression analysis identified an inverse association between the efficacy of fracture prevention and increased body mass index. Thus, we recommended that the vitamin D dose should be adjusted according to BMI based on further confirmation.