Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics. (7th April 2021)

• Record Type: Journal Article
• Authors: Jiang, Hailong; Li, Jingchao; Shi, Changrong; Ming, Jiang; Zhang, Deliang; Zhuang, Rongqiang; Guo, Zhide; Zhang, Xianzhong
• Is Part Of: Biomaterials science. Volume 9:Number 9(2021)
• Page Start: 3507
• Page End: 3515
• Publication Date: 2021-04-07
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d1bm00173f
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : This study highlights the FY-Pd@Au NCs for highly efficient theranostic applications and provides a new paradigm to exploit to potential of 19 F MRI probes. Abstract : As one of the emerging modalities of magnetic resonance imaging (MRI), 19 F MRI is highly conducive for the specific detection and imaging of deep-seated tumors, with negligible background. However, most 19 F MRI probe designs are constructed with organic CF3, which contains rich fluorine atoms, and few of the fluorine-containing groups are equipped with therapeutic function. Herein, we designed a versatile 19 F MRI-based theranostic nanoplatform, FY-Pd@Au nano-metallacages (FY-Pd@Au NCs), which not only serve as a 19 F MRI/CT/PAI contrast agent, but also produce reactive oxygen species (ROS) by type I photodynamic therapy (PDT) pathway, as well as heat for photothermal therapy (PTT), under the single NIR laser irradiation. Overall, this work successfully built a theranostics nanoplatform based on 19 F MRI.