Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans. Issue 10 (19th May 2021)

• Record Type: Journal Article
• Authors: Yu, Hao-Bing; Yin, Zi-Fei; Gu, Bin-Bin; Zhang, Jian-Peng; Wang, Shu-Ping; Yang, Fan; Lin, Hou-Wen
• Is Part Of: Natural product research. Volume 35:Issue 10(2021)
• Page Start: 1620
• Page End: 1626
• Publication Date: 2021-05-19
• Subjects: Dactylospongia elegans -- meroterpenoid -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1633644
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new sesquiterpene quinones/hydroquinones, 20-demethoxy-20-isopentylaminodactyloquinone D (1 ), 20-demethoxy-20-isobutylaminodactyloquinone D (2 ), and 19-methoxy-dictyoceratin-A (3 ), and five known related compounds (4 −8 ) were isolated from the marine sponge Dactylospongia elegans . Their structures were elucidated by spectroscopic analysis, ECD calculation, single-crystal X-ray diffraction, and comparison with the literature. Compounds 3 and 5 −8 exhibited activities against the human cancer cell lines DU145, SW1990, Huh7, and PANC-1 with IC50 values ranging from 2.33 to 37.85 μM. GRAPHICAL ABSTRACT: