Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus. (16th April 2021)

• Record Type: Journal Article
• Authors: Nolan, Nathanial S; Adamson, Samantha; Reeds, Dominic; O'Halloran, Jane A
• Is Part Of: Open forum infectious diseases. Volume 8:Number 5(2021)
• Publication Date: 2021-04-16
• Subjects: bictegravir -- diabetes -- HIV -- hyperglycemia -- integrase strand transfer inhibitors; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab077
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART. Abstract : We provide increased awareness among clinicians of the potential for antiretroviral therapy-associated hyperglycemia with bictegravir-containing regimens.