The significant role of dietary intake of vitamin D in non-menopausal women health. Issue 5 (28th May 2021)

• Record Type: Journal Article
• Authors: Milovanovic, Jasmina R.; Milovanovic, Olivera Z.; Tomic Lucic, Aleksandra; Djokovic, Jelena; Cvetkovic, Tatjana; Zivanovic, Slavoljub; Barjaktarevic, Ana; Pantovic, Suzana; Radovanovic, Milan; Dimitrijevic, Aleksandra; Jankovic, Slobodan; Velickovic Radovanovic, Radmila
• Is Part Of: Women & health. Volume 61:Issue 5(2021)
• Page Start: 420
• Page End: 430
• Publication Date: 2021-05-28
• Subjects: 25-hydroxy vitamin D -- diet intake of vitamin D -- healthy non-menopausal women -- population pharmacokinetic analysis -- vitamin D; Women -- Health and hygiene -- Periodicals; Women -- Health and hygiene -- United States -- Periodicals; Women's health services -- Periodicals; Gynecology -- Periodicals; Women in medicine -- Periodicals; 613.0424405
• DOI: 10.1080/03630242.2021.1917480
• Languages: English
• ISSNs: 0363-0242

Abstract

ABSTRACT: Optimal vitamin D status is very important for reflecting not only bone but overall woman's health. The aim of the study was to determine pharmacokinetic variability of 25-hydroxy vitamin D, to reveal and quantify the most significant factors that affect its variability in the population of healthy non-menopausal women using the population pharmacokinetic (PopPK) approach. The study population consisted of 74 healthy reproductive women aged from 35 to 50 years, without the use of any supplement. A population pharmacokinetics analysis was conducted using a nonlinear mixed-effects model software. A total of 35 factors were assessed: demographic, clinical, biochemical data and lifestyle factors. The average age and bodyweight of our participants were 40.11 ± 4.35 years 65.30 ± 6.80 kg, respectively. The observed mean serum concentration of 25-hydroxy vitamin D was 26.51 ± 13.49 ng/mL with a wide range of 6.97 to 59.89 ng/mL. Development final PopPK model of the clearance of 25-hydroxy vitamin D showed that only the average daily dose of vitamin D intake from food had a significant influence, with a magnitude of its effects of 0.00401. These results could help when individualizing vitamin D intake in the form of supplements, especially during the wintertime, in healthy reproductive women.