A double-layer dura mater based on poly(caprolactone-co-lactide) film and polyurethane sponge: preparation, characterization, and biodegradation study. Issue 18 (30th April 2021)

• Record Type: Journal Article
• Authors: Jin, Shu; Pu, Yuji; Guo, Zhaoyuan; Zhu, Wangwei; Li, Sai; Zhou, Xi; Gao, Wenxia; He, Bin
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 18(2021)
• Page Start: 3863
• Page End: 3873
• Publication Date: 2021-04-30
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00454a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A double-layer composite of the PCLA film and PU sponge with good biodegradability and biocompatibility was designed as a potential dural substitute. Abstract : Synthetic, biodegradable polymers hold great potential in dura mater substitution. In this study, a dura mater-mimetic double-layer film@sponge composite was developed. The composite contains a poly(caprolactone- co -lactide) (PCLA) film and polyurethane (PU) sponge, which simulates the hard and soft layers of dura mater, respectively. PCLA films were prepared by a solution-casting method and showed excellent mechanical properties and tolerance to water. PU sponge was hydrophilic and had a high water-absorption rate (about 500%). The double-layer composite (film@sponge) integrated the good mechanical properties of the films and the good water absorption of the sponge. The excellent biocompatibility and biodegradability of the PCLA film@PU sponge composites were verified by in vitro degradation and cytotoxicity study and the in vivo implantation in the back of rats. Importantly, the film@sponge composite had a suitable degradation rate and good biocompatibility, holding potential in the field of dural repair.