Co-self-assembly of multiple DNA origami nanostructures in a single pot. Issue 39 (15th April 2021)

• Record Type: Journal Article
• Authors: Johnson, Joshua A.; Kolliopoulos, Vasiliki; Castro, Carlos E.
• Is Part Of: Chemical communications. Volume 57:Issue 39(2021)
• Page Start: 4795
• Page End: 4798
• Publication Date: 2021-04-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00049g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We demonstrate co-self-assembly of two distinct DNA origami structures with a common scaffold strand through programmable bifurcation of folding pathways. Abstract : Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot. Relative yields were tuned by adjusting concentrations of the competing strands, correlating well with folding kinetics of individual structures. These results can faciliate efficient fabrication of multi-structure systems and materials.