Diagnostic and therapeutic nanoenzymes for enhanced chemotherapy and photodynamic therapy. Issue 18 (4th May 2021)

• Record Type: Journal Article
• Authors: Cong, Cong; He, Yuchu; Zhao, Shuxian; Zhang, Xuwu; Li, Lei; Wang, Desong; Liu, Lanxiang; Gao, Dawei
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 18(2021)
• Page Start: 3925
• Page End: 3934
• Publication Date: 2021-05-04
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb02791j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We creatively designed a nanodrug delivery system of MnO2 -PTX/Ce6@lips based on the catalytic activity of MnO2 NPs. We synthesized a highly dispersible catalase-like nanozyme and successfully encapsulated it into liposomes. Abstract : Nanozymes, as a kind of artificial mimic enzymes, have superior catalytic capacity and stability. As lack of O2 in tumor cells can cause resistance to drugs, we designed drug delivery liposomes (MnO2 -PTX/Ce6@lips) loaded with catalase-like nanozymes of manganese dioxide nanoparticles (MnO2 NPs), paclitaxel (PTX) and chlorin e6 (Ce6) to consume tumor's native H2 O2 and produce O2 . Based on the catalysis of MnO2 NPs, a large amount of oxygen was produced by MnO2 -PTX/Ce6@lips to burst the liposomes and achieve a responsive release of the loaded drug (paclitaxel), and the released O2 relieved the chemoresistance of tumor cells and provided raw materials for photodynamic therapy. Subsequently, MnO2 NPs were decomposed into Mn 2+ in an acidic tumor environment to be used as contrast agents for magnetic resonance imaging. The MnO2 -PTX/Ce6@lips enhanced the efficacy of chemotherapy and photodynamic therapy (PDT) in bearing-tumor mice, even achieving complete cure. These results indicated the great potential of MnO2 -PTX/Ce6@lips for the modulation of the TME and the enhancement of chemotherapy and PDT along with MRI tracing in the treatment of tumors.