Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice. Issue 2 (2008)

• Record Type: Journal Article
• Authors: Pokharel, Yuba Raj; Lim, Sung Chul; Kim, Sang Chan; Heo, Tae-Hwe; Choi, Hoo Kyun; Kang, Keon Wook
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 5:Issue 2(2008)
• Page Start: 173
• Page End: 180
• Publication Date: 2008
• Subjects: anti-dermatitic activity -- atopic dermatitis -- NF-κB -- Sopungyangjae-Tang -- TARC; Alternative medicine -- Periodicals; 615.505
• DOI: 10.1093/ecam/nem015
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT.