Mathematical Modelling of Immune Response in Tissues. Issue 1 (2009)

• Record Type: Journal Article
• Authors: Su, B.; Zhou, W.; Dorman, K. S.; Jones, D. E.
• Is Part Of: Computational and mathematical methods in medicine. Volume 10:Issue 1(2009)
• Page Start: 9
• Page End: 38
• Publication Date: 2009
• Subjects: immune system; biological sensor; regulatory mechanism; chemotaxis process; homogenization; numerical simulation; Medicine -- Computer simulation -- Periodicals; Medicine -- Mathematical models -- Periodicals; 610.11
• DOI: 10.1080/17486700801982713
• Languages: English
• ISSNs: 1748-670X

Abstract

Abstract : We have developed a spatial–temporal mathematical model (PDE) to capture fundamental aspects of the immune response to antigen. We have considered terms that broadly describe intercellular communication, cell movement, and effector function (activation or inhibition). The PDE model is robust to variation in antigen load and it can account for (1) antigen recognition, (2) an innate immune response, (3) an adaptive immune response, (4) the elimination of antigen and subsequent resolution of the immune response or (5) equilibrium of the immune response to the presence of persistent antigen (chronic infection) and the formation of a granuloma.