Monte Carlo simulation to assess free space and end-weld thickness variation effects on dose rate for a new Ir-192 brachytherapy source. (July 2021)

• Record Type: Journal Article
• Authors: Angelocci, Lucas Verdi; Daruich de Souza, Carla; Pantelis, Evaggelos; Nogueira, Beatriz Ribeiro; Zeituni, Carlos Alberto; Chueri Martins Rostelato, Maria Elisa
• Is Part Of: Applied radiation and isotopes. Volume 173(2021)
• Publication Date: 2021-07
• Subjects: Iridium-192 seeds -- Brachytherapy -- Dosimetry -- Monte Carlo simulations -- Source production; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2021.109709
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: A new Iridium-192 seed for brachytherapy is under development. Specific dose rate contribution by two different factors were evaluated: the effect from movement of the core in the free space within the seed and the effect of the end-weld thickness variation. Both were investigated through use of the Monte Carlo radiation transport code MCNP6 and an in-house routine programmed with MATLAB. Differences greater than 15% compared to results from the nominal seed were found near the source, indicating a significant dose variation. Graphical abstract: Image 1 Highlights: We are developing an Ir-192 seed for cancer treatment. This seed is currently under dosimetric evaluation. Two factors were investigated: core movement and end-weld thickness variation. Investigated through use of the Monte Carlo - MCNP6 and MATLAB. Differences greater than 15% compared to results from the nominal seed were found.