1, 2, 3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens. (15th May 2021)

• Record Type: Journal Article
• Authors: Michaut, Mathieu; Steffen, Alexandre; Contreras, Jean-Marie; Morice, Christophe; Schalk, Isabelle J.; Plésiat, Patrick; Mislin, Gaëtan L.A.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 40(2021)
• Publication Date: 2021-05-15
• Subjects: Antibiotic -- Gold(I) complex -- Azide-alkyne Huisgen cycloaddition -- Clostridium difficile -- Staphylococcus sp. -- Enterococcus sp.; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2021.127879
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Abstract: Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile .