The effect of platelet-rich plasma in patients with early hip osteoarthritis: a pilot study. Issue 3 (18th September 2020)

• Record Type: Journal Article
• Authors: Ortiz-Declet, Victor; Iacobelli, David A; Battaglia, Muriel R; Go, Cammille C; Maldonado, David R; Lall, Ajay C; Domb, Benjamin G
• Is Part Of: Journal of hip preservation surgery. Volume 7:Issue 3(2020)
• Page Start: 496
• Page End: 502
• Publication Date: 2020-09-18
• Subjects: Hip joint -- Surgery -- Periodicals; 617.581059
• DOI: 10.1093/jhps/hnaa044
• Languages: English
• ISSNs: 2054-8397

Abstract

Abstract: We investigate whether platelet-rich plasma (PRP) injections can improve symptoms and function in patients with mild to moderate osteoarthritis (OA). Data were prospectively collected and retrospectively reviewed for all patients receiving PRP intra-articular hip injections between February 2017 and June 2017. The inclusion criteria were patients with a well-preserved joint space (Tönnis 0 or 1) whose magnetic resonance imaging (MRI) findings demonstrated degenerative joint disease or a Tönnis grade of 2. The patient-reported outcomes (PROs) used were the modified Harris Hip Score (mHHS), Hip Outcome Score-Activities of Daily Living Subscale (HOS-ADL), Hip Outcome Score-Sports Specific Subscale (HOS-SSS), International Hip Outcome TOOL (iHOT-12), Single Assessment Numeric Evaluation (SANE) and Mental and Physical aspects of the Veteran RAND 12 Item Health Survey (VR-12M and VR-12P). The visual analog scale (VAS) was utilized to indicate pain. Nine patients (11 hips) were eligible for inclusion. All PROs and VAS improved from pre- to post-injection. These improvements were present at the 3-month follow-up visit and stable until the 12-month follow-up. There was statistically significant improvement for mHHS ( P < 0.001), HOS-ADL ( P = 0.006), iHOT-12 ( P = 0.003) and VR-12M ( P = 0.005) at 12 months post-injection. Similarly, VAS improved from 4.1 to 2.3, although the change was not statistically significant. PRP injections significantly improved PROs in all measured scales at time points up to a year after intervention, except for VR-12P and HOS-SSS. In conclusion, patients with early OA of the hip had significant improvement of patient-reported functional outcomes up to 12 months after PRP intra-articular injections.