Application of the REVEAL risk score calculator 2.0 in the PATENT study. (1st June 2021)

• Record Type: Journal Article
• Authors: Benza, Raymond L.; Farber, Harrison W.; Frost, Adaani E.; Ghofrani, Hossein-Ardeschir; Corris, Paul A.; Lambelet, Marc; Nikkho, Sylvia; Meier, Christian; Hoeper, Marius M.
• Is Part Of: International journal of cardiology. Volume 332(2021)
• Page Start: 189
• Page End: 192
• Publication Date: 2021-06-01
• Subjects: Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2021.03.034
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Regular risk assessment is recommended in pulmonary arterial hypertension (PAH) management to improve patient outcomes. The REVEAL risk score (RRS) predicts survival in patients with PAH, including those from the PATENT study, which assessed riociguat, a soluble guanylate cyclase stimulator approved for PAH treatment. An updated version, RRS 2.0, has been developed to further refine risk prediction. Methods: This post hoc analysis of PATENT-1 and its open-label extension PATENT-2 ( n = 396) assessed RRS 2.0 score and risk stratum and their association with survival and clinical worsening-free survival (CWFS). Results: At PATENT-1 Week 12, riociguat improved RRS 2.0 versus placebo (least-squares mean difference versus placebo: −1.0 [95% confidence interval − 1.4 to −0.6; p < 0.0001]) and more patients improved risk stratum with riociguat (57%) versus placebo (42%). These improvements were maintained at PATENT-2 Week 12. RRS 2.0 score and risk strata at PATENT-1 baseline and Week 12 were significantly associated with survival and CWFS in PATENT-2 ( p < 0.0001); change in RRS 2.0 score from PATENT-1 baseline to Week 12 was also significantly associated with outcomes. Conclusions: These data suggest that RRS 2.0 has clinical utility in predicting long-term outcomes and monitoring treatment response in patients with PAH. Highlights: We assessed RRS 2.0, an updated version of REVEAL risk score in the PATENT study. Riociguat improved RRS 2.0 and risk strata in PATENT. RRS 2.0 was associated with survival and clinical worsening-free survival. This study suggests that RRS 2.0 can predict outcomes in patients with PAH.