One-Step Preparation of Green Fabric for Continuous Antibacterial Applications. (March 2021)

• Record Type: Journal Article
• Authors: Huang, Rongkang; Hu, Minghui; Liang, Weiwen; Zheng, Juanjuan; Du, Yang; Lin, Yanhuan; Wang, Huaiming; Guo, Wentai; Zeng, Zhantao; Li, Chuangkun; Li, Ming; Wang, Hui; Zhang, Xingcai
• Is Part Of: Engineering. Volume 7:Number 3(2021)
• Page Start: 326
• Page End: 333
• Publication Date: 2021-03
• Subjects: Green chemistry -- Polypropylene scaffold -- Polydopamine -- Triclosan -- Antibacterial; Engineering -- Periodicals; Engineering -- China -- Periodicals; 620.005
• DOI: 10.1016/j.eng.2020.08.022
• Languages: English
• ISSNs: 2095-8099

Abstract

Abstract: Polypropylene (PP) scaffolds are the most commonly used biomedical scaffolds despite their disadvantages, which include problems with adhesion, infection, and inflammatory responses. Here, we report on the successful development of a facile one-step method to fabricate a series of novel triclosan polydopamine polypropylene (TPP) composite scaffolds and thereby effectively improve the biocompatibility and long-term antibacterial properties of PP scaffolds. The antibacterial triclosan can effectively interact with dopamine during biocompatible polydopamine formation on the PP scaffold by one-step green fabrication. Thanks to the sustained release of triclosan from the biocompatible polydopamine coating, a 5 mm × 5 mm sample of TPP-coated scaffold made with a triclosan concentration of 8 mg·mL −1 (referred to herein as TPP-8) exhibited a continuous antibacterial effect against both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) for more than 15 d, at maximum antibacterial volumes of 2 and 5 mL, respectively. Our study establishes a new direction for facile long-term antibacterial studies for medical applications.