Vaccines for COVID-19: learning from ten phase II trials to inform clinical and public health vaccination programmes. (April 2021)

• Record Type: Journal Article
• Authors: Bhopal, Sunil S.; Olabi, Bayanne; Bhopal, Raj
• Is Part Of: Public health. Volume 193(2021)
• Page Start: 57
• Page End: 60
• Publication Date: 2021-04
• Subjects: Public health -- Vaccine -- Vaccination -- COVID-19 -- SARS-CoV-2; Public health -- Periodicals; Public health -- Periodicals; Electronic journals; 362.1
• DOI: 10.1016/j.puhe.2021.01.011
• Languages: English
• ISSNs: 0033-3506

Abstract

Abstract: Public health professionals and clinicians, in many countries, are immersed in the ongoing and upcoming vaccination programmes for COVID-19. Published information from vaccine trials is complex. There are important and helpful insights about the nature of the available and forthcoming vaccines, immune responses and side-effects from phase II trials. We have systematically summarised information from 10 such trials on the nature of the vaccines, exclusions from the trials, immunological effects and side-effects. Some important information within these trial reports is not available in the phase III trial articles, so a complete picture requires examination of phase II and phase III trials for each vaccine. We recommend our systematic approach for the examination of other upcoming COVID-19 vaccine phase II and III trials.