Synthesis and antifungal activity of new hybrids thiazolo[4, 5-d]pyrimidines with (1H-1, 2, 4)triazole. (15th May 2021)

• Record Type: Journal Article
• Authors: Blokhina, Svetlana V.; Sharapova, Angelica V.; Ol'khovich, Marina V.; Doroshenko, Irina A.; Levshin, Igor B.; Perlovich, German L.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 40(2021)
• Publication Date: 2021-05-15
• Subjects: Hybrids -- Thiazolo-pyrimidins -- Triazole -- Lipophilicity -- Solubility -- Antifungal activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2021.127944
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Synthesis and antifungal activity of hybrids of thiazolo[4, 5- d ]pyrimidines with (1H-1, 2, 4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.