LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack. (1st July 2021)

• Record Type: Journal Article
• Authors: Venkatesh, Jaganathan; Wasson, Marie-Claire D.; Brown, Justin M.; Fernando, Wasundara; Marcato, Paola
• Is Part Of: Cancer letters. Volume 509(2021)
• Page Start: 81
• Page End: 88
• Publication Date: 2021-07-01
• Subjects: Long-non-coding RNAs -- microRNAs -- Sponging -- Cancer stem cells -- Epithelial-mesenchymal transition; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2021.04.002
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are master regulators of gene expression and are functionally important mediators in these mechanisms of pathogenesis. Intricate crosstalks between these non-coding RNAs form complex regulatory networks of post-transcriptional gene regulation. Depending on the specific lncRNA/miRNA interaction, the lncRNA-miRNA axis can have tumor suppressor or oncogenic effects, thus defining the lncRNA-miRNA axis is important for determining targetability. Herein, we summarize the current literature describing lncRNA-miRNA interactions that are critical in the molecular mechanisms that regulate EMT, CSCs and drug resistance in breast cancer. Further, we review both the well-studied and potential novel mechanisms of lncRNA-miRNA interactions in breast cancer. Highlights: LncRNAs interact with microRNAs via multiple mechanisms regulating gene expression. Sponging of microRNAs by lncRNAs regulates critical pathways in breast cancer. LncRNA-microRNA axes are potential therapeutic targets in breast cancer.