Efflux Limits Tumor Drug Delivery Despite Disrupted BBB. (June 2021)

• Record Type: Journal Article
• Authors: Griffith, Jessica I.; Sarkaria, Jann N.; Elmquist, William F.
• Is Part Of: Trends in pharmacological sciences. Volume 42:Number 6(2021)
• Page Start: 426
• Page End: 428
• Publication Date: 2021-06
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2021.03.001
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al . demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.