Superbranched polyglycerol nanostructures as drug delivery and theranostics tools for cancer treatment. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Rahman, Mahfoozur; Alrobaian, Majed; Almalki, Waleed H.; Mahnashi, Mater H.; Alyami, Bandar A.; Alqarni, Ali O.; Alqahtani, Yahya S.; Alharbi, Khalid S.; Alghamdi, Saad; Panda, Sunil Kumar; Fransis, Alberte; Hafeez, Abdul; Beg, Sarwar
• Is Part Of: Drug discovery today. Volume 26:Issue 4(2021)
• Page Start: 1006
• Page End: 1017
• Publication Date: 2021-04
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2020.11.007
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: HPG have branching ranges from 0.5 to 0.6 with linear, crosslinked and dendritic form. LPGs and HPGs of B100 kDa found superior blood compatibility over PEG. HPG biodegradation can be altered by incorporating biodegradable functional groups. Biocompatibility and ease of design make easy for HPG to nanocarrier development. The presence of many functional groups in HPG makes it for theranostics action. Abstract : Hyperbranched polymers (HBPs), such as hyperbranched polyglycerols (HPGs) with a dendritic configuration, have been recognized for their excellent biocompatibility and multifunctionalization. HPGs have been studied for use in the delivery diagnostic, imaging and therapeutic molecules in the area of nanobiomedicine. They show superior characteristics to linear polymers and dendrimers, such as compact structure, a simple manufacturing process with easy functionalization ability, low viscosity, and high stability. Owing to these advantages, HPGs are now considered promising carriers for drug delivery, diagnostics, imaging, and theranostics applications for cancer treatment. In this review, we also discuss safety aspects of HPG-based nanoformulations in various animal models and the clinical translation status of such polymers for real-time applications. Teaser: Hyperbranched polyglycerols (HPGs) are better alternatives to dendrimers and polyethylene glycol (PEG) for their chemical functionality, stability, and wider ability in designing nanocarriers for chemotherapeutic applications.