Discordant results in 18F-FDG PET/CT and ultrasound-based assessment for axillary lymph node metastasis detection: A large retrospective analysis in 560 patients with breast cancer. (2021)

• Record Type: Journal Article
• Authors: Parisse-Di Martino, Sandrine; Faure, Christelle; Mognetti, Thomas
• Is Part Of: Cancer treatment and research communications. Number 27(2021)
• Publication Date: 2021
• Subjects: Breast cancer -- Axillary lymph node -- 18F-FDG PET/CT -- Axillary ultrasound -- Discordant results -- Accurate interpretation
• DOI: 10.1016/j.ctarc.2021.100344
• Languages: English
• ISSNs: 2468-2942

Abstract

Highlights: 18F-FDG PET/CT and ultrasound assessments show less than 4% of discordant results. 18F-FDG PET/CT allow to accurately assess axillary node involvement in patients with aggressive breast cancer. 18F-FDG PET/CT is especially appropriate for axillary lymph nodes smaller than 1 cm. Is sentinel lymph node biopsy systematically required for appropriate diagnosis ? Abstract: Purpose: Ultrasound is the recommended modality to assess axillary lymph node involvement in breast cancer; nevertheless, 18 F-fluorodeoxyglucose ( 18 F-FDG) integrated positron emission tomography/computed tomography (PET/CT) diagnostic efficiency, to identify suspicious lesions, is also considered. We aim to report discrepancies in ultrasound and 18 F-FDG PET/CT results. Methods: This single-centered retrospective analysis selected consecutive patients with invasive ductal biopsy-proven breast cancer, for whom divergent 18 F-FDG PET/CT and axillary ultrasound imaging (and/or core needle biopsy if available) had been performed, and described clinical, histological, imaging, and surgery data. Results: This retrospective study included 560 patients and identified discordant results between 18 F-FDG PET/CT and ultrasound (suspicious 18 F-FDG PET/CT and normal ultrasound imaging and/or core needle biopsy) in 20 (4%) patients. Axillary lymph node involvement was confirmed in 17 (85%) out of these 20 patients. Further, the lymph nodes were smaller than one centimeter in 12 (60%) patients, macrometastasic involvement (involvement >2 mm) was detected in 13 (65%) patients, and more than 3 macrometastases were detected in 6 (30%) patients. All patients had an aggressive breast cancer. The sentinel node biopsy performed in 9 (45%) patients allowed to reveal lymph node involvement, even in cases of macrometastatic involvement. Conclusion: Discordant results were issued from normal ultrasound imaging and/or core needle biopsy, and suspicious 18 F-FDG PET/CT revealed that 18 F-FDG PET/CT may overcome axillary ultrasound limits in the specific case of aggressive breast cancers, especially for axillary lymph nodes smaller than 1 centimeter. Sentinel node biopsy remains a valuable aid, even in patients with macrometastatic involvement.